Mesenchymal stem cells (MSCs) are multipotent stem cells found in the bone marrow that are important for making and repairing skeletal issues, such as cartilage, bone, and the fat found in the bone marrow. They make up a small portion of cells in the bone marrow. However, there have been successful isolation to enhance its study. The broad immunomodulatory properties of human mesenchymal stem cells (MSCs) have allowed for wide application in regenerative medicine as well as immune/inflammatory diseases, including unmatched allogeneic use(Yen et al., np, 2020). MSC therapy has emerged as the potential preventative and curative therapies for the novel Corona Virus (Covid-19). Furthermore, MSCs may be useful for immune/inflammatory pulmonary conditions.
Gene-editing can alter a range of inheritable diseases by permanently removing or changing troublesome coding in embryos. Thewere born in China in November 2018 (BBC, 2020). However, the issue is still a grey area, and other scientists worry that modifying the genome of an embryo could cause unintended harm, not only to the individual but also to future generations that inherit these same changes. Gene-editing uses technology such as the CRISPR, which scans the genome looking for the right location, and then uses “molecular scissors” to snip through the faulty DNA (BBC, np). However, the technology can cause harm by cutting out too much DNA and thus altering important genes. The unnecessary altering of genes could potentially cause cancer. The first gene-edited issue sparked a lot of debate among ethicists and scientists worldwide. Many mainstream scientists think it is too unsafe to try, and some denounced the Chinese report as human experimentation. The global backlash led to the jailing of the scientist responsible for the act.
“Gene-edited babies: Current techniques not safe, say experts.”BBC News, 3Sept.2020, www.bbc.com/news/health-54014969.
Yen, B.L., et al. “Current Status of Mesenchymal Stem Cell Therapy for Immune/inflammatory Lung Disorders: Gleaning Insights for Possible Use in COVID19.”Stem Cells Translational Medicine (AlphaMed Press), 11June2020, stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/sctm.20-0186.
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