GluD1 expression and Localization to unique synapses
The ionotropic family has two members (GluD1 and GluD2). According to Konno et al., 2014, the expression of GluD1 concerning synapses and circuit formation has not much information. However, considering the structural similarities between GluD1 and GluD2, there are possible commonalities between the two synapses. For example, GluD1 and GluD2 are similar in expressing PF synapses but differ in neuronal expression. The difference shows the actions of GluD1 in regulating PF interneurons connectivity and the activities of GluD2 on PC (Konno et al., 2014). Previous research shows that deletion of GluD1 causes repetitive behavior and possible reversed learning deficit (Liu et al., 2020). Together with a change in synaptic expression of proteins, the discovery explains the linkage between GluD1 and the regulation of synapses and circuits relevant to neuropsychiatric disorders.
The mapping of GluD1 is an important step in understanding the interconnection between GluD1 and GluD2 in the cerebellum. GluD2 mainly has several functions in PC where GluD1 is present in measurable quantity. The presence of GluD1 one in the forebrain shows the interrelation in functionality between the GluDs in a molecular-anatomical platform (Nakamoto et al., 2020). GluD1 has a unique expression pattern at multiple synapses. The cerebellar interneurons, central amygdala, and BNST present Axo-somatic distribution of GluD1.