Glud1- Cbln Ampa Receptor Signaling In Pain
GluD1-Cbln1 has a vital role in the pain pathway of the central amygdala. According to Gandhi et al. 2021, pain is a condition that is associated with neuronal dysfunction. However, the synaptic mechanisms associated with prolonged pain are not well known. Gandhi et al. 2021, “We found that the synaptic organizer glutamate delta one receptor (GluD1) is expressed postsynaptically at parabrachial-central laterocapsular amygdala (PB-CeLC) glutamatergic synapses at axo-somatic and punctate locations on protein kinase C δ -positive (PKCδ+) neurons.” From the finding, the removal of GluD1 may alter neurotransmission at parabrachial-central laterocapsular amygdala synapses. Accumulating evidence implicates the amygdala receives nociceptive information through the spino-parabrachial-amygdaloid pain pathway (Kissiwaa and Bagley, 2018).