Synapses vary in structure and function. Different researches present information linking memory storage to synapses. The storage function is why the synapse has specialized molecular structures that make them unique (Sossin, 2018). The delta family entails different receptors. Glutamate delta-1(Glud1) and delta-2(Glud2) are sub-family under the delta family called ionotropic glutamate receptors (iGlurs) (Khan, 2017). The sub-family is unique but presents structural similarities to other sub-families like the amino-terminal domain, transmembrane domain, and ligand-binding domain (Elegheert et al., 2016). However, a distinction develops in their arrangement and functioning, which shows their importance in the system.
D-serine is one of the three amino acids present in the mammalian brain. However, the acid’s percentage is lower than the other two (D-aspartate and D-alanine) (MacKay et al., 2019). The acid attaches to the Glud LBD in the brain. It is responsible for prompting Depression at parallel fiber (PF) to Purkinje cell (PC) during the initial development stages (Kristensen et al., 2016). The binding can also create metabotropic currents. Therefore, after glutamate binding, a postsynaptic membrane-bound G-protein activates, which in turn helps in signal transmission.